A recent network meta-analysis of RCT comparing incretin-based drugs for the management of obesity in non-diabetic subjects supported the superiority of tirzepatide in achieving a greater percentage of BW loss compared to semaglutide 2.4 mg and liraglutide 3.0 mg (5.13%, 95% CI 9.82 to 0.68, tirzepatide 15 mg vs
DISCERN involves culturing fibroblasts from a skin biopsy and assessing multiple molecular signatures
Emerging approaches advocate for a paradigm shift, integrating multimodal biomarkers, such as neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau protein (Tau), with in vivo imaging (fMRI, and PET), AI-driven patient stratification and adaptive trial designs
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